利多卡因对人、大鼠离体子宫平滑肌的松弛作用

The relaxative effects of lidocaine on isolated human and rat smooth muscle of uterus

利多卡因2.6×10^(-4)mmol/ml人离体子宫颈肌、体肌自发性收缩及时催产素诱发人、大鼠离体子宫颈肌、体肌的收缩均有明显抑制作用。4.3×10^(-4)m mol/ml 利多卡因对高 K+去极化后Ca^(2+)所引起的人离体子宫收缩也有抑制作用,其作用可被增加溶液中的 Ca^(2+)浓度所对抗。

The spontaneous contraction of isolated humanuterus and the contraction of isolated human andrat uterus induced by oxytocin were markedly inhi-bited by lidocaine at the concentration of 2.6×10^(-4)mmol/ml.The contraction of isolated human uterusinduced by Ca^(2+) after high K^+ depolarization wasinhibited by lidocaine at the concentration of 4.3×10^(-4)mmol/ml.Their depression effect was abolis-hed by addition of Ca^(2+) to the bath fluid.