摘要
为探讨原发性高血压的遗传作用及遗传方式,我们采用家系调查的方法,调查了110例先证者和110例对照者的家系。结果表明,原发性高血压有家族聚集性。同胞中患病分离比为0.14,小于0.25。先证者组的一级亲属患病率是对照组的2.97倍,其遗传度为59.04±4.80%,符合多基因遗传病的特点,表明遗传因素对高血压病起重要作用。
In order to explore the heriditary effect and pattern of essential bypertention, the family aggregation of blood pressure of 110 families were investigated with another 110 families as a control. The results indicated that essential hypertention had aggregation in families. According to the binomial distribution, the distribution of study value and thoory value existed striking divergence. The incidence of hypertension among the first degree relatives in the studied group was 1.97 time higher than the controle. The countnig of essential hypertention gsepa rate ratio amoteug siblings revealed that essential hypertention was a polygenic disease influonced by environmental factors and heritability played an important role.
出处
《中国医科大学学报》
CAS
CSCD
1989年第5期362-365,共4页
Journal of China Medical University
关键词
高血压
流行病学
家系调查
遗传
genetic epidcmiology
familial aggregation
separate ratio
heritability
familial study
