e抗原阳性产妇之婴儿对乙肝疫苗免疫效果观察

FIVE-YEAR OBSERVATION OF IMMUNE RESPONSE IN INFANTS OF HBeAg POSITIVE MOTHERS TO HEPATITIS B VACCINE

本文报告用国产乙肝血源疫苗接种于e抗原阳性产妇之新生儿观察免疫后抗体的持续时间和保护状态。36名中31名产生抗-HBs,经5～6年,其中16名幼儿的抗-HBs仍在10mIU/ml以上,占61.29%,抗-HBs降到10mIU/ml以下者12名,占38.71%。36名婴儿初免后,6个月内HBsAg阳转者5人,到5年时仍为阳性,均演变为HBsAg慢性携带者。31名抗-HBs阳性的幼儿中,5～6年时有6人被HBV感染,表现抗-HBc阳性,但其HBsAg仍为阴性。HBV感染与抗体滴度偏低有关。抗体消失或降到10mIU/ml以下时,宜进行乙肝疫苗再接种,以增强其免疫能力。

Immune response in 36 infants of HBeAg positive mothers to hepatitis B vaccine was observed in a period from Nov. 1981 to Sept. 1983. All infants were followed up for 5-6 years. Five of 36 children became HBsAg positive carriers (carrier rate was 13.88%), the remaining 31 children maintained anti-HBs anti-HBs concentrations of 19 of these 31 children (61.29%) were still above 10 mIU/ml, while 12 (38.71%) below 10 mIU/ml. During these 5～6 years, in 6 of 31 children, their anti-HBc became positive, but their HBsAg were still negative. For maximum protection, when anti-HBs concentration fell below 10 mIU/ml, a second booster is needed.