麝香的药理研究 Ⅲ.麝香抗炎作用原理

The Pharmacological Activities of Musk Ⅲ. on the Mechanisms of Its Anti-inflammatory Activities

麝香水溶物可降低大鼠肾上腺内丙种维生素(VC)含量、提高外周血皮质酮含量,切除肾上腺其抗炎作用消失,但切除垂体其抗炎作用依然存在,说明肾上腺与麝香水溶物的抗炎作用密切相关。麝香水溶物能抑制血小板聚集。提高血浆cAMP水平的这些作用与非甾体抗炎药相似;但麝香水溶物能增强615小鼠免疫溶血反应的作用,提示其可能通过免疫调节而发挥抗炎作用。

The water soluble fraction (WSF) of musk was shown to decrease the vitamine C content of the adrenal gland in mice and to increase plasma cor-ticosterone levels in rats. The anti-inflammatory effect of WSF was not affected by hypophysectomy in the rat but was completely abolished by adr-enalectomy in mice, indicating that the adrenal gland may play an important role in mediating the anti-inflammatory effect of musk.The WSF was capable of inhibiting ADP or collageninduced platelet aggregation in rats. In the meantime, there was a potentiation of immunoh-emolysis in mice and an elevation of the plasma level of cAMP in rats. The implications of these changes in the anti-inflammatory effects of musk are discussed.