雷公藤多甙片所致闭经原因的探讨

Cause of Amenorrhea after treatment with Tripterygium Wilfordii F

目前雷公藤在国内已用于多种疾病的治疗,但在治疗过程中发现女性患者出现闭经,其发生率为16.6～72％。为探讨雷公藤多甙片(tripterygium wilfordii hookf,T_2)导致闭经的原因,作者对类风湿性关节炎等用雷公藤多甙片治疗发生闭经的患者进行生殖内分泌临床与实验室观察。

Fourteen lemale patients with rheumatoid arthritis who developed ame-norrhea after treatment with T2 were investigated endocrinologically. FSH and LH levels began to rise after 2-3 mon and reached menopausal levels at 4-5 mon of treatment. E2 levels began to drop after 3-4 mon and reached very low levels at 5 mon of treatment. This indicates that the site of action of T2 is the ovary. The factors effecting amenorrhea may be related to dosage and the status of reproductive function. Cytotoxicity might be the mechanism of action of T2. In 9 cases (64.3%), menses returned after discontinuing treatment for 7 mon. Amenorrhea due to T2 is reversible when the reproductive functions are in the active stage.