硅纤维对体外小鼠巨噬细胞介导的细胞毒活性的影响

The in Vitro Effect of Silica Fibers on Macrophage-mediated Cytotoxic Activities in Mice

本文报告促癌物硅纤维在体外对小鼠巨噬细胞(M)介导的细胞毒活性的影响.主要指标有三个:①M对瘤细胞的溶解作用(MTC);②M对瘤细胞的增殖抑制作用(MTCS):③抗体依赖性细胞毒作用(ADCC)。发现硅纤维的存在明显削弱了MTC和ADCC,但可轻度促进MTCS。进一步的研究证明,硅纤维既影响M激活因子对M的激活作用,又影响M对瘤细胞的溶解及抑制增殖过程。在ADCC中,加大抗体浓度并不能抵消硅纤维的抑制作用.

The in vitro effects of silica fibers on macrophage-mediated cytotoxic activities in mice were studied, including 1) macrophage-mediated tumor cytoly-sis (MTC), 2) macrophage-mediated tumor cytostasis (MTCS) and 3) antibody-dependent cell-mediated cytolysis (ADCC). we found that silica fibers markedly inhibited both MTC and ADCC but slightly promoted MTCS. Silica fibers were active during the activation phase mediated by macropha-ge-activating factor as well as in the effector phases of MTC and MTCS. In ADCC, increasing the antibody titer could not abrogate the inhibitory effect of silica fibers.