围手术期胃肠外输入脂肪乳剂的廓清研究

Studies of parenteral Fat Emulsion Clearance in Peri-operative Patients

对围手术期病人以糖与脂肪的混合能源作为完全胃肠外营养支持。研究结果表明,中国人在围手术期能耐受50%脂肪热卡的TPN支持.患者在手术后可以接受满意的胃肠外营养支持而无高血糖的副作用。

In a group of 24 peri-operative patients, all received total parenteral nutrition support (artificial gut support) for 11 days using a mixed energy source (50% from glucose and 50% from liposyn-2/intralipid). Intral-ipid was used in the fat clearance. A test dose of 10% or 20% Intralipid (Kabivitrum) was administered over a 5 hours period at a dosage of 0.17± 0.017g fat/kg/h. The results show that after 11 days of fat infusion, the fat clearance was accelerated (P <0.05). One day after operation(POD + 1), the elimination of fat emulsion was also obviously accelerated (P<0.01). Blood chemistry values reflecting organ function did not change following fat emulsion infusion. In this prospective study, Chinese patients well tolerated 50/% fat calorie TPN support in the peri-operative period. Patients received satisfactory parenteral nutrition support without high blood glucose side effects in the post-operative period.