慢性肺心病呼吸衰竭患者治疗期间血清镁的动态观察

Dynamic Observation of Serum Magnesium Level during Treatment of Patients with Chronic Cor Pulmonale and Respiratory Failure

慢性肺心病(简称肺心病)与低血镁的密切关系,近年来已引起学者们的注意。但有关报道多属─过性观察,迄今尚未见长期动态观察血镁浓度演变的报道。作者系统动态地检测48例肺心病呼吸衰竭患者治疗期间的血清镁(简称血镁)浓度,以探讨肺心病与低血镁的关系.

Serum magnesium (Mg) levels in 48 patients (486 person-time) with chronic cor pulmonale and respiratory failure were observed dynamically during treatment. Results showed a tendency towards hypomagnesemia in patients with acute exacerbation and in the early stage of treatment (1-10 d), but while only a few patients in the convalecence stage. The serum Mg level was found to be positively correlated with PaO2 (r = 0.146, P<0.05) and blood chlorine (Cl-) level (r = 0.236,P<0.01) and negatively correlated with PaCO2 (r=-0.012, P<0.05). All patients with hypomagnesemia had acid-base disorder. We found that the prognosis of patients with chronic cor pulmonale was closely related to hypomagnesemia. We also found thaf in order to cure patients with hypomagnesemia, combined treatment was necessary for long-term improvement of the general condition.