摘要
用3,4-二氨基取代苯分别与氰基氨基甲酸甲酯及取代苯甲醛作用,合成了5(6)-(取代氨基甲酰)苯并咪唑-2-氨基甲酸甲酯(Ⅰ_1～22)和2-取代苯基-5(6)-取代苯并咪唑(Ⅱ_1～12)。经感染棘球蚴的小鼠试验,多数化合物对棘球蚴有不同程度的作用,其中化合物Ⅰ_(10,19)及Ⅱ_1较强,但均不如甲苯咪唑。
The synthesis of methyl 5(6)-(substituted carbamoyl) benzimi-dazole-2-carbamates (I, Table 2)and 2-(substituted phenyl)-5(6)-(substituted car-bamoyl)benzimidazoles(II_1 Table 3) is reported. In screening test against hydati-dosis of mice, I_(10,19) and II_1 seemed to be more effective, but none shown bettereffect than mebendazole.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1989年第3期110-115,共6页
Chinese Journal of Pharmaceuticals
关键词
苯并咪唑
化合物
棘球蚴药
合成
antihyditidesis drug, methyl 5(6)-(substituted carbamoyl) benzimidazole-2-carbamate, 2-(substituted phenyl)-5(6)-(substituted carbamoyl)-benzimidazole
