肠溶脲酶剂型的制备和口服治疗兔慢性肾衰竭试验

PREPARATION OF ENTERIC UREASE DOSAGE FORMS AND ORAL TREATMENT OF RABBITS SUFFERED FROM RENAL FAILURE

筛选适当的肠溶脲酶剂型,并观察其口服治疗兔慢性肾衰竭的疗效。包衣法制备的肠溶脲酶胶囊其酶活力的保留率远比有机相分离法、喷雾干燥法制备的肠溶脲酶微囊为佳。前者在4℃贮藏101天后酶活力无明显下降。口服酶胶襄治疗肾衰竭家兔的试验证实,其对体内血尿素氮含量的下降有良好的作用,用药组动物存活期明显延长,但对肌酐和电解质平衡则无明显的影响。

The retained urease.activity of the enteric urease capsules prepared by coating was much higher than those of the microcapsules prepared by organic separation and spray drying techniques. The enzyme activity in the capsules did not substantially change after 101 days storage in 4℃. After the treatment of the rabbits of chronic renal failure by the capsules, bloodd urea nitrogen was decreased and the survival duration of the animals was prolonged. However, electrolyte balance and serum creatmine were not influenced obviously