摘要
报道了N^1-[4＇-[3-(二烷胺基)甲基和3, 5-双[(二烷胺基)甲基]-4-羟基苯胺基]-6-三氟甲基-2-嘧啶基]-N^3-(4-卤苯基)胍的合成。合成了24个化合物,经药理初筛表明,该类型化合物对感染沙鼠的棉鼠丝虫微丝蚴或成虫有一定的杀灭作用。
Twenty four N^1- [4-[3-(dialkylamino) methy 1-, and 3,5-bis[(dialkylamino) methyl]-4-hydroxyanilino]-6-trifluoromethyl-2-pyrimidinyl]-N^3-(4-halogenophenyl) guanidines (1) had been synthesized and screened witn Litemosoidos carihii. They were found to possess microfilaricidal and/ or macrofiaricidaleffects.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1989年第7期313-318,共6页
Chinese Journal of Pharmaceuticals
关键词
丝虫
卤苯基胍
合成
抗丝虫病药
synthesis, antifilarial activity, N^1-(4-substituted amino-6-trifluoro-methyl-2-pyrimidinyl)-N^3-(p-halogenophenyl) guanidines
