经口补充谷氨酰胺对烧伤大鼠小肠功能的影响

THE EFFECT OF ORAL GLUTAMINE SUPPLEMENTATION ON SMALLINTESTINALFUNCTION IN BURNED RATS

大鼠２０％ＢＳＡⅢ°烧伤后１４天，门静脉、后腔静脉和腹主动脉血浆谷氨酰胺（Ｌ一Ｇｌｕｔａｍｉｎｅ，Ｇｌｎ）含量均明显降低，小肠粘膜的蛋白质、ＤＮＡ、ＡＴＰ含量及乳糖酶活性均明显低于正常。烧伤后在饲料中补充２％或５％Ｇｌｎ，大鼠血浆Ｇｌｎ水平，小肠粘膜的蛋白质、ＤＮＡ、ＡＴＰ含量，以及乳糖酶活性均明显高于烧伤对照和补充甘氨酸（Ｇｌｙ）组，其中ＡＴＰ含量和乳糖酶活性接近正常组。补充５％Ｇｌｎ的大鼠血浆Ｇｌｎ水平高于２％Ｇｌｎ组，其他指标则并不优于补充２％Ｇｌｎ的动物。上述结果表明，烧伤后经口补充Ｇｌｎ，有助于支持肠道的物质和能量代谢，防治或减轻肠道功能的损伤。

he effect of oral glutamine supplementation after 3rd degrce burn inju-ry of 20%BSA on the dorsum of Wistar male rats was investigated。On the 14th day postburn the plasma glutamine levels in abdominal aorta,inferior vena cava and portal vein were significantly lower than the unhurnedrats(normal control);protein,DNA,ATP levels and lactase activities insmall intestinal mucosa were lowered too。When the postburn rats were fed dietscontaining 2%or 5%Gln(burn group III & IV)for 14 days,the changes ofth:abov-ementioned items were not significant.Only plasma glutamine levelin hurn group IV was significantly higher than burn group III,otherindices had no difference between groups III and IV。In those fed diet contai-ning 2% glycine(burn group II),the changcs in plasma glutamine and smallintestinal function were not improved.These findings suggested that gluta-mine was needed following burn injury,it might be used to prevent and treatpostburn lesions of intestine。