1-硫代-1-磷杂-2,6,7-三氧杂双环[2.2.2]辛烷基-4-亚甲基硫醚及其亚砜的合成

Study on the Synthesis of 1-Sulfur-1-Phospha-2,6,7 Trioxabicyclo [2.2.2] Octyl-4-Methyl Thioethers and Its Sulfoxides

本文通过Williamson反应,合成了9个双环笼状硫代磷酸酯的硫醚衍生物3a～i。以3b,3c为例研究了硫醚衍生物的还原性,并合成相应的亚砜化合物4b,4c。讨论了亚砜化合物的立体化学。

Nine new thioethers of caged bicyclic thiophosphates 3a- i were prepared by Williason Reaction. Oxidation of the thioethers 3b and 3c gave the corresponding sulfoxide 4b and 4c which containning one chiral sulfur atom. The stereochemistry of the sulfoxide was also discussed.