手性钯络合物催化下2-硝基环酮的不对称烯丙基化反应

Chiral Palladium Complex Catalyzed Asymmetric Allylation of 2-Nitrocycloketones

在用氮杂冠醚改良的手性二茂铁膦与钯的络合物催化下,2-硝基环酮可进行不对称烯丙基化反应。讨论了配位基的形状,反应物的构造,碱的类型以及反应时间对反应速率和立体选择性的影响。通过增加反应的空间位阻改进了反应的立体选择性。

Asymmetric allylation of 2-nitrocycloketones was catalyzed by palladium with chiral ferrocenylphosphine ligand modified by monoaza crown ethers (A-D). The effects of the structure of ligands and substrates, the type of alkali, and reaction time on rate of reaction and stereoselectivity were discussed. The stereoselectivity was improved by increasing steric hindrance of the reactions.