5-丁基-9-苯基-4,5,6,9-四氢苯并[d.e]噁唑[5,4-g]-异喹啉-4,6-二酮的合成

The Synthesis of 5-Butyl-9-Phenyl-4,5,6,9-Tetraydrobenzo [d.e]-Oxazolo[5.4-g]-Isoquinoline-4,6-Dinones

本文给出了一条较好的制备5-丁基-9-苯基-4,5,6,9-四氢苯并[d.e]吣唑[5,4-g]-异喹啉-4,6-二酮的反应路线,即:先由4-溴-1,8-萘酐经亚胺化、硝化、水解和还原等反应制得N-丁基-3-硝基-4羟基-1,8萘酰亚胺,再在硼酸的存在下,将亚胺与苯甲酰氯反应可得到目标化合物。文中给出了该化合物的质谱、核磁共振、红外、紫外和荧光等光谱数据。

N-butyl-3-amino-4-hydroxyl-1,8-naphthalimine was synthesized from 4-bromo-1,8-naphthalic anhydride via the reaction of imination, nitration, hydrolysis and reduction. The better reaction route was given. It can react with benzoyl chloride in the presence of boric acid and form the title compound. The Mass, 1H NMR, IR and UV spectra of the compound were given.