抑制血小板聚集对犬缺血心肌收缩功能的改善效应

IMPROVING EFFECT OF INHIBITING PLATELET AGGREGATION ON MYOCARDIAL CONTRACTILE FUNCTION DURING ISCHEMIA IN DOGS

本实验在18只麻醉开胸犬观察了心肌缺血早期,抑制血小板聚集功能对左室肌整体和局部收缩功能改变的影响。结果表明,阻断冠脉血流后,PAgR显著增大,LVSP、dp/dt_(max)、V_(CE)和CO降低,缺血边缘区ESL延长,ESWT、%△L和%△WT均减小.阻断冠脉前1h,静脉输注AAs,抑制血小板聚集功能,可明显改善缺血左室肌的收缩功能。

The effect of inhibiting platelet aggregation on changes of whole and regional systolic function of left ventricular muscle during the early phase of myocardial ischemia was observed in 18 anesthtized open-chest dogs. The results showed that platelet aggregation rates were markedly increased, left ventricular systolic pressure, dp / dt_(max)velocity of the contractile elements shorten. ing and cardiac output were significantly decreased after coronary occlusion. On the other hand, end systolic segment length, percent segment shortening, end systolic wall thickness, and percent wall thickening in the border ischemic zone were all decreased Changes in aforementioned parameters of left ventricular systolic function after myocardial ischemia were relieved by giving an intravenous injection of arginine aspirin to inhibit the function of platelet aggregation at 1 hour before coronary occlusion