千针万线草环肽A的结构修正

REVISION OF THE STRUCTURE OF STELLARIN A

从云南民间药物千针万线草（Ｓｔｅｌｌａｒｉａｙｕｎｎａｎｅｎｓｉｓ）的根中分离到一新环肽ｓｔｅｌｌａｒｉｎＡ。前报主要利用快速原子轰击质谱确定其结构为ｃｙｃｌｏ（Ｇｌｙ－Ｐｒｏ－Ｐｈｅ－Ｔｙｒ－Ｇｌｙ－Ｇｌｙ－Ｐｒｏ）。最近利用最新二维核磁结合快速原子轰击质谱及酶降解重新考察了其结构，修正为ｃｙｃｌｏ（Ｇｌｙ－Ｐｒｏ－Ｐｈｅ－Ｐｒｏ－Ｇｌｙ－Ｔｙｒ－Ｇｌｙ）。

From the fresh roots of Stellaria yunnanensis Franch.a new cyclopeptide named stellarin ,was obtained and its structure was established to be cyclo(Gly-Pro-Phe-Tyr-Gly-Gly-Pro)by FAB-MS in a previous communication. Recently by a combination of 2D-NMR, FAB-MS and enzvmatic degradation,its structure was re-examined and revised to cyclo(Gly-Pro-Phe-Pro-Gly-Tyr-Gly)。