摘要
作者报告了４８例急性白血病患者的骨髓髓系白血病细胞集落（ＡＭＬ－ＣＦＵ）和粒－单核细胞集落（ＧＭ－ＣＦＵ）体外培养的结果。结果表明，急非淋白血病治疗前ＡＭＬ－ＣＦＵ数比缓解组高，而ＧＭ－ＣＦＵ比缓解组低，差异显著。观察１４例急非淋白血病患者治疗前ＡＭＬ－ＣＦＵ数与预后的关系，发现ＡＭＬ－ＣＦＵ丛／集比值具有判断预后的价值，ＡＭＬ－ＣＦＵ数与此无关。本文还提出，ＡＭＬ－ＣＦＵ培养用于微小残余白血病的诊断必须结合形态观察。
This paper reports studies onthe bone marrow cells from 48 patients with acute leukemia by means of in-vitro AML-CFU and GM-CFU cultures.The results showed that in untreated patients the incidence of AML-CFU was significantly higher than that in the remission group.Our studies on the relationship of the incidence of AML-CFU and prognosis in acute myeloid leukemia indicated that the lower ratio of cluster to colony might predict a favorable result,but the AMLCFU incidence did not provide any prognostic information. The authors suggest that the diagnosis of minimal residual leukemia by AML-CFU culture be established in combination with cytomorphological observation.
