摘要
本实验观察了１４例膀胱移行细胞癌（ＴＣＣ）患者手术前后及１５例正常人外周血淋巴细胞染色体畸变和脆性位点。结果发现，手术前后ＴＣＣ患者的脆性位点表达率、染色体总断裂率均比对照组有显著性增高（Ｐ＜０．０１），而且ＴＣＣ组各脆性位点检出频率显著高于对照组，依次为３ｐ１４、１ｑ２１、５ｑ３１（Ｐ＜０．０１）和１ｐ３２、１１ｑ１３、１７ｑ２１、１３ｑ１３（Ｐ＜０．０５）。作者认为脆性位点表达率可作为膀胱癌的一个易患性指标。
The total chromosomal breakages and the fragile sites of lymphocytes in the peripheral blood in 14 preoperative and 14 postoperative patients with bladder transitional cell carcinoma (TCC) and 15 normal individuals were observed.The results showed that the spontaneous fragile site expression frequencies and the total chromosomal breakage frequencies of preoperative and postoperative patients with TCC were significantly higher than those of the normal control group (P<0.01).Statistical analyses showed that 3p14、1q21、5q31 (P<0.01) and 1p32、11q13、17q21、13q13(P<0.05)were located in order at the fragile sites.Therefore,the expression frequency of fragile sites might serve as an indicator of cancer susceptibility.
关键词
膀胱肿瘤
家族
细胞遗传学
外科手术
Bladder neoplasms/diag
Bladder neoplasms/familial
Chromosome aberrations
Chromosome fragile site
Lymphocytes
