生大黄对大鼠离体肠管电活动和收缩活动的影响

Effects of Rhubarb on Electrical and Contractive Activities of Isolated Intestine in Rats

大黄对整个结肠的电活动有明显的兴奋作用。兴奋的特点为群集性放电。锋电频率明显增快,辐度明显增高,收缩活动增强。大黄对十二指肠也有兴奋作用,使锋电频率增快,而对空肠几乎没有影响。此外,还观察到阿托品可阻断大黄对肠管的兴奋效应。

The results indicate that electrical activity of colon is obviously excited by rhubarb (Rheum tanguticum). The characteristics of excitement is cybotaxis discharge. It has been found that the frequency and amplitude of spike potential increase obviously, and the contraction enhances. Spike potential frequency of duodenum excited by rhubarb is increased but that of jejumum is hardly excited. It has also been found that the exciting effect of rhubarb on colon can be blocked by atropine.