摘要
通过15例大剂量化疗的恶性滋养叶细胞肿瘤病人，采用自身对照的方法，研究G－CSF的临床效果。结果：1）用药组中性粒细胞绝对数（ANC）＜2000／mm3的为40％（6／15），明显低于对照组的87％（13／15），而ANC的最低点明显高于对照组。2）用药组ANC持续低水平的天数明显少于对照组（p＜0．01）；而从ANC最低点恢复至＞2000／mm3所需时间平均为0．9天．明显短于需4．3天的对照组（P＜0．05）。3）血小板计数两级无差异（P＞0．05）。4）用药组无继发感染发生，感染发生率明显低于对照组的13％（2／15）。5）用药组ANC随人数的变化，至双峰曲线。6）100％（15／15）病例用G－CSF后出现轻的腰背酸以说明G－CSF有促进中性粒细胞恢复，减少化疗病人继发感染的作用，且毒副作用轻。
The clinical effect of G-CSF producetl by the Zhongwai Company was obsetved through 15 cases of trophoblastic tumor pa-tients treated by large dosage chemotherapy, using the method of auto contrast. 1) In the using drug group, the absolute neutrophil count (ANC) was < 2000/mm3 in 40 % (6/15), which was obviously lower than that of the control group in which was 87 % (13/15 ), and the ANC nadir was obviously higher than that of the control groupl 2) ln same group,tbe number of days in wbich ANC remained at low level was obviously less than that of the control group (p<0. 01),and the average time required to recover from ANC nadir to more than 2000/mm3 was 0. 9 day. whlch was obviously shorter than that of the control group in which was 4. 3 days (p<0.05); 3)The two groups showed no dif-ference in platelet count (p>0.05); 4) In the medicine treatment group, not a single case developed secondary infection, the infection occurring rate was lower than that of the control group (p<0.05); 5)With using of G-CSF, 100% had lumbago and hackache,but not severe. It indi-cates G-CSF could protnote neutrophil recovery,decrease the occurrence of secOndary infections in chemotherapy patients and has mild of toxi city and side effects.
