摘要
本文采用PCNA和p53蛋白对45例胶质瘤进行联合探讨，发现两种核内蛋白均随肿瘤病理级别的升高而标记阳性升高。Ⅰ级组，未复发组的阳性率与Ⅱ级组、Ⅲ～Ⅳ级组、复发组相比较有显著差异（p＜0.01）．这提示肿瘤分级与病人的预后有关。本实验还证实胶质瘤的PCNA和p53蛋白易在细胞浆内表达，说明胶质瘤核与胞浆间有一定物质交换，提示可作为阳性判断．
45 cases with glioma were studied by PCNA and p53 protien. It is found that the positive rates of two markers were increased with pathological grade of gliorna. Ⅰ grades group and unrecurrence group were compared with Ⅱ grade group, Ⅲ- Ⅳ gradegroup and recurrence group, there were significant difference (p<0. 01 ). The result suggested that the pocitive rates of PCNA and p53protein were closely related to the prognosis. Also,it is found that expression of PCNA and p53 protein was occurred in cytoplasm ofglioma. The result showed that there was certain material exchange betwcen nuclear and cytoplasm of glioma, and this speific phenomenon meant the positive.
关键词
胶质瘤
核内蛋白
免疫组化
Gliorma Nuclear protein Immunohistochemistry
