山麦冬水溶性提取物对麻醉猫血液动力学的影响

Hemodynamic Effects of Water Soluble Extract of Liriope spicata Lour on Anesthetized Cats

给麻醉猫静脉注射山麦冬水溶性提取物1.75g/kg,其LV dp/dt max增加86%,t-dp/dtmax缩短28%。CO,CI,SI,和LVWI分别增加146%,151%,150%和194%。心率轻度减慢,SVR降低48%。本品0.7g/kg,iv,LV dp/dt max增加38%,CO增加44%,t-dp/dt max缩短20%,SVR降低20%。结果提示,本品有正性肌力作用,并能改善心脏泵功能。

The effects of water soluble extract of Liriope spicata on acute hemodynamics were studied in anesthetized cats. The results showed that LV dp/dt max was increased by 87%, whereas tdp/dt max was shortened by 28% after administration of WSEL (1.75g/kg, ⅳ). At the same time CO, CI, SI, and SVWI were increased by 146, 151, 153, and 194%, respectively, HR was declined slightly. SVR was reduced by about 48%. WSEL (0.79/kg, ⅳ) induced an increase of 38% in LV dp/dt max, 44% in CO, 50% in SI and a decrease of 20% in t-dp/dt max and 20% in SVR. Preliminary results indicated that WSEL increased ventricular contractile force and might increase cardiac pump function.