针灸对过敏性哮喘患者粘膜SIgA免疫功能调整作用的研究

Studies on Regulatory Effects of Acupuncture on Mucosal Secretory IgA in Patients with Allergic Asthma

本文从唾液、鼻分泌液、疾液中SIgA和外周血淋巴细胞PWM（Pokeweeklmitogen）刺激培养上清液中IgA含量测定两个方面，对针灸调整过敏性哮喘患者粘膜SIgA免疫功能进行了研究。结果表明，针灸能明显降低患者唾液、鼻分泌液中SIgA（P＜0．01，＜0．02）和总IgA（P＜0．02，＜0．02）含量，有效控制患者的迟发哮喘反应。针灸对患者外周血淋巴细胞PWM刺激培养上清液中IgA含量的影响无显著性，与细胞免疫在其中的调节作用有关。

We studied mucosal SIgA immunity of patients with allergic asthma treated by acupuncture. Our results showed that concentrations of SIgA and total IgA in saliva (P<0. 01, <0. 02) and in nasal secretions (P<0.02,<0.02), and levels of IgE in sera (P< 0. 001 ) from patients with allergic asthma were significantly decreased after treatment with acupuncture. The results suggested that attacks of delayed and immediate allergic asthma could be effectively inhibited by acupuncture. The facts that there were no significant changes in IgA in supernatenats of peripheral blood lymphocytes stimulated with PWM of patients with allergic asthma after treated by acupuncture were associated with regulation of negative feedback of T-lyrnphocyte expressing IgA-R and it released bound factor of IgA in production of polymeric IgA