中耳局部应用氟嗪酸及庆大霉素对豚鼠Corti′s器及前庭终器的影响

Effects of Ototopically Applied Ofloxacin and Gentamicin on Corti's Organ and Vestibular Organ of the Guinea Pig

本研究采用鼓室植管法，于正常豚鼠中耳局部连续应用氟嗪酸及庆大霉素溶液后，观察并比较了两种药液对内耳Ｃｏｒｔｉ′ｓ器及前庭终器的组织学影响。结果表明，氟嗪酸对内耳的感觉细胞无明显的影响，而庆大霉素则有严重的耳蜗毒性及前庭毒性。

The morphological effects of ofloxacin and gentamicin on Corti's and vestibular organs of the guinea pig were observed and compared after the drugs were topically applied repeatedly to the middle car by tubulus implanted in tympanum.The results demonstrated that there was no obvious effect of ofloxacin on sensory cells of inner car, but gentamicin had serious cochleotoxicity add vestibulotoxicity .