乳腺单纯癌病理组织学亚型分型的探讨

Histopathologic Sub-types of Breast Carcinoma Simplex and Its Relationship with Prognosis

本文对409例乳腺单纯癌的各种组织形态因素与预后进行了研究。发现癌周浸润程度、组织学级别、癌细胞排列方式、淋巴细胞浸润程度及腺样结构与预后关系密切,而弹力纤维增生、坏死及钙化,则与预后关系不大。作者根据镜下癌周浸润程度,把单纯癌分为ⅠⅡ、Ⅲ亚型。3个亚型的10年生存率依次为90.3％、65.1％、21.2％;淋巴结转移率依次为41.9％、68.4％及78.7％,均有非常显著差别(P<0.01)。本分型对临床有实用意义。

The histomorphologic features and prognosis of 409 cases of carcinoma simplex of the breast were analysed. Based on the degree of peripheral infiltration beyond the tumor margin, breast carcinoma simplex can be divided into Ⅰ, Ⅱ,Ⅲsub-types. The 10-year survival rate and lymph node metastatic rate in these 3 sub-types were 90.3%, 65.1%, 21.2% and 41 .9%, 68.4%, 78.7% respectively, all with statistical signi- ficance (P<0.01). It is concluded that there was clinical importance in the sub-types.