血清铜、锌对原发性肝癌诊断和疗效判断的价值

Value of Serum Copper and Zinc Determination in Diagnosis and Evaluation of Therapeutic Results in Primary Hepatic Carcinoma

本文研究了50例肝癌患者血清铜、锌等指标的变化,结果表明,肝癌组血铜明显高于肝硬化纽(n=42)和对照组(n=30),而血锌无显著性差异。血铜还与肝癌肿瘤体积呈正相关。8例治疗前后对照CT检查和血铜测定发现,肿瘤体积缩小者5例,血铜亦有不同程度降低。我们认为血铜结合γ-GT测定可以作为肝癌诊断的有用指标之一,血铜水平还可帮助判断肿瘤的体积和观察肝癌病人的治疗效果。

Serum levels of copper and zinc were determined in 50 patients with primary liver cancer (PLC, group Ⅰ), 42 patients with liver cirrhosis (group Ⅱ),and 30 healthy individuals (group Ⅲ). The results showed that the mean value of serum Cu in group Ⅰ was 162±40μg/dl, higher than those of group Ⅱ (117±28μg/dl) and groupⅢ (105±20μg/dl). The positivity rate for patients with PLC at 130μg/dl of Cu was 80%, and the sensitivity and specificity rates at 150μg/dl were 60% and 86% respec- tively. Value of serum Cu>150μg/dl in combination with γ-GT>100 u would raise specificity and positive predictive value to as high as 1.0. There is close relationship between serum Cu level and tumor size. No significant differences of serum zinc ex- isted among the three groups of individuals. The authors concluded that the deter- mination of serum Cu might be of practical value in the diagnosis of PLC, and also in evaluating treatment effect.