63例何杰金氏病长期随访结果分析

A Long Term Follow-up Result of 63 Cases of Hodgkin's Disease

1971年3月至1982年3月,我科收治何杰金氏病63例。首先以MOPP(氮芥、长春新碱、甲基苄肼和强的松),COPP(环磷酰胺、长春新碱、甲基苄肼和强的松)或MBPP(氮芥、争光霉素、甲基苄肼和强的松)方案化疗,再给予病灶局部放疗,肿瘤量3,500-4,000rads。完全缓解后,间断巩固化疗3年。其Ⅰ、Ⅱ、Ⅲ期的5、10年生存均为100％。Ⅳ期的5、10年生存率均为25％。完全缓解病人5年内复发率为13.95％。化疗加局部放疗与不规则大面积野放疗相比也有同样疗效。

From March 1971 to March 1982, 63 patients with Hodgkin's disease were treated by MBPP (HN2, BLM, PCZ and PDN), MOPP (HN2, VCR, PCZ and PDN) or COPP (CTX, VCR, PCZ and PDN) regimens and followed by local irradiation with a tumor dose of 3,500-4,000 rads. After complete remission, intermittent chemotherapy was given for 3 years. The 5-and 10-year survival rates were 100% for stage Ⅰ,Ⅱ and Ⅲ lesions and 25% for stage Ⅳ. The 5 years recurrence rate was 13.95% for pa- tients with complete remission. The results of chemo-radiotherapy was as effective as total nodal irradiation.