胃液和唾液CEA临床意义的探讨

Significance of CEA Determination in Gastric Juice and Saliva

本文用酶联免疫吸附夹心法检测94例胃良、恶性疾患的胃液及27例唾液CEA含量。其中,22例胃癌胃液CEA含量(152.2±85.6ng/ml)明显高于26例浅表性胃炎(26.4±34.6ng/ml)、17例萎缩性胃炎(33.5±35.0ng/ml)、16例肠上皮化生(38.9±49.1ng/ml)及13例异型增生(68.8±46.6ng/ml),异型增生组又明显高于浅表性胃炎和萎缩性胃炎组。27例唾液CEA(18.7±23.2ng/ml)与胃液CEA无相关性。免疫组化结果表明组织CEA染色与胃液CEA含量无恒定关系。并讨论了胃液和唾液内CEA测定的临床意义。

Quantitative determinations of CEA in gastric juice using immunoperoxidase method were carried out in 94 patients with various gastric diseases (adenocarcinoma 22, superficial gastritis (SG) 26, atrophic gastritis (AG) 17, metaplasia 16, dysplasia 13). Meanwhile CEA in saliva was assayed as well in 3 cases of gastric adenocarci- noma and 24 cases of gastritis using the same technic. The results showed that CEA level in gastric juice was significantly higher in gastric cancer(152.2±85.6 ng/ml)than in SG (26. 1±34.6ng/ml), AG (33.5±35.0 ng/ml), metaplasia (38.9±49.1ng/ml) and dysplasia (68.8±46.6ng/ml). The level of CEA in dysplasia was also higher than in SG and AG. A relationship was not found between CEA in gastric juice and in tissue stain, nor between CEA in saliva or gas- tric juice.