血清酸溶性糖蛋白测定在癌瘤诊治中的应用

Determination of Serum Acid Soluble Glycoproteins in the Diagnosis and Treatment of Cancers

本文报道用酚试剂显色法检测了15种肿瘤患者185例和216例健康人血清ASP含量。结果表明,在恶性肿瘤方面肾癌、肺癌和肝癌100％高于健康人,二者间统计学差别非常显著(P<0.01),并随治疗好转而降低或降至正常,而鼻咽癌、食管癌及贲门癌均无显著差别(P>0.05)。在良性肿瘤如肠息肉、子宫肌瘤和甲状腺瘤患者中ASP含量均在正常范围内。血清ASP测定,对某些恶性肿瘤的诊断和疗效观察有一定价值。

The serum concentrations of acid soluble glycoproteins (ASP) were determined in 185 patients with fifteen different types of cancer and in 216 healthy subjects by colour-developing method with phenolic reagents. The results showed that the concentrations of serum ASP in the malignant tumors of kidney,lung and liver were significantly higher than that in healthy subiects (P<0.01) and that the concentrations of ASP were declined below or equal to normal level with improvement of the disease. In patients with nasopharyngeal carcinoma, esophageal carcinoma and gastric cardiac cancer, the levels of serum ASP were also higher than that of healthy subjects although with no statistical significances (P>0.05). In benign tumours, shch as intestinal polyposis, myoma of uterus and adenoma of thyroid, the levels of serum ASP were within normal limit. The results indicate that the determination of serum ASP is of great value in the diagnosis and posttherapeutic monitoring of some of the malignant tumours.