硬膜外腔注射吗啡辅助乙酰普马嗪用于晚期癌症镇痛

Epidural Injection of Morphine as an Adjunct to Plegicil in Alleviating Cancer Pain

32例晚期癌性疼痛,经硬膜外腔注入吗啡辅助乙酰普马嗪,镇痛时间平均62小时±12小时,2例镇痛时间长达35天已无剧痛。用药过程中未发现恶心、呕吐、搔痒、呼吸抑制和尿潴留等。注入后患者呈现安静,此法不但能加强镇痛作用,又不影响身体机能,还能对抗单一使用吗啡的副作用,是目前较好的辅助药物。为使病人无痛安度余生,我们每24小时给药1次。并经临床证实吗啡4mg,乙酰普马嗪30mg的效果已能达到镇痛要求,故无需更大剂量。

Thirty two patients with advanced cancerous pain were treated by epidural space injection of morpbine adjuvant with plegicil. All patients had some degree of allevi- ation after injection and a majority obtained good pain relief. The mean duration of extrication from pain was 62±12 hours, with 2 cases lasted as long as 35 days. There were no complications such as nausea, vomiting, itching, respiratory insufficiency or retention of urine occurred. The use of plegicil can not only enhance the analge- sic effect but also obviate the side-effect when morphine was given alone. The do- sage used was morphine 4 mg, plegicil 30 mg, given via an indwelling catheter inserted into the epidural space beforehand.