癌症患者血浆唾液酸、过氧化脂质及红细胞超氧化物歧化酶临床价值探讨

Determination of Plasma Sialic Acid,Lipoperoxide and Erythrocyte Superoxide Dismutase in Cancer Patients

通过对76例正常人,64例癌症患者血浆唾液酸(Sialic Acid.SA),过氧化脂质(Lipo-peroxide.LPO)和红细胞超氧化物歧化酶(Superoxide Dismutase,SOD)的测定,发现癌症患者血浆SA及LPO水平明显高于正常人(P值均小于0.001),红细胞SOD比活性则明显低于正常人(P<0.001),65例非癌患者(冠心病患者)与正常人相比,血浆SA含量无差别,血浆LPO水平和红细胞SOD比活性发生与癌症患者相似的变化,但相比之下非癌患者变化的程度小于癌症患者。本实验观察提示:血浆SA水平的测定对癌症尤其对呼吸系统癌,何杰金氏病,恶性淋巴瘤具有诊断价值,血浆LPO和红细胞SOD可作为辅助诊断指标。

The levels of Plasma Sialic Acid(SA), Lipoperoxide (LPO), and specific activ- ity of erythrocyte Superoxide Dismutase (SOD) were determined in 76 healthy indi- viduals, 64 patients with cancers and 65 non-cancer patients. In patients with vari- ous cancers, both plasma SA and LPO levels were significantly increased (P<0.001) and on the other hand, the specific activity of erythrocyte SOD was significantly decreased (P<0.001). In non-cancerous patients the SA concentration showed no change, while LPO level was elevated and specific activity of erythrocyte SOD declin- ed. The clinical significance of these three markers was discussed.