同位素质谱用于医学的最新进展

The Latest Advance in Using Isotope Mass Spectrometry to Solve Medical Science Problems

利用（１３）Ｃ、（１４）Ｃ、（１５）Ｎ等同位素作为示踪剂来探测胃幽门螺杆菌（简称ＨＰ）的试验在近几年有了很大的进展，为同位素质谱在医学上的应用开辟了一条新途径。（１３）Ｃ－尿素呼吸试验具有无放射性、无任害、无污染、对患者无特殊要求等优点，而且方法简便，诊断的正确率达到９３％以上。（１４）Ｃ－尿素呼吸试验的灵敏度很高，准确率达到９６以上（但（１４）Ｃ有轻微的放射性，对孕妇和婴儿应当慎用）。近年来本实验室与医院合作开发，已用于临床诊断。（１５）Ｎ－尿素排泄试验具有简单、精确、灵敏度高、无放射性、无侵害等优点，准确率达到９６％，有条件的地方可推广应用。

The test for the detection of Helicobacter Pylon(HP) infection using the isotope 13C, 14C and 15N as a tracer has grealy advanced in recent years. It makes a new way for using isotope to solve medical science problems. The 13C -urea breath test has advantages such as non-invasive,non-radioactive and no pollution. It has no special demand to patients. The method is convenient. The correction rate of diagnosis has been more than 93%. The 14C-urea breath test has a very high sensitivity. Its correction rate has been more than 96%, but 14C has light radiation,it had better not be used in children and pregnant woman. The 15N-urea excretion test is a simple,high sensitive,non-invasive and non-radioactive test. Its correction rate is 96%. It can be popularized in any area which have certain conditions.