脂质体包裹对汉防已甲素细胞毒性影响的实验研究

Experimental Studies on Liposome Encapsulation in Cytotoxicity of Tetrandrine

观察了汉防已甲素在脂质体包裹前后的细胞毒性改变。结果显示，在40μg／ml浓度时，汉防己甲素包裹前后对大鼠肺泡巨噬细胞的酵母吸附功能、胞浆游离K＋和Ca2＋含量和细胞骨架调控能力的影响有明显的不同。提示脂质体包裹可减轻汉防已甲素的细胞毒性。为开发该药的新剂型作了有益的尝试。

Changes in the cytotoxicity of tetrandrine before and after liposome encapsulation on rat alveolar macrophages in vitro were ohserved. Results suggested that there was a siginificant differentiation on the adsorptive capacity to yeast, and the level in cytoplasmic free calcium and potassium, and the cytoskeletal control of macrophages at the concentration of 40μg/ml. Experiments showed that liposome encapsulation may attenuate cytotoxicity of tetrandrine.