葛根黄酮滴丸体外释放度的研究

In Vitro Dissolution Test of Flavonoid Pilulae from Gegen

用熔融法将葛根总黄酮与载体PEG－4000、PEG－6000制成不同比例的滴丸，进行了体外释放度的研究，并与市售愈风宁心片、葛根黄酮作了比较，药物溶出试验表明：PEG－4000与PEG－6000的配比对药物的溶出没有影响，PEG－4000／药物的比值增大，溶出速度增大，反之溶出则减少，但达到90％以上时，则药物的溶出降低，以PEG－4000与药10：1为最佳溶出。葛根黄酮滴丸（10：1）T50为11．56min，而市售愈风宁心片T50为94．79min，经t检验P＜0．01。

Flavonoid Pilulae from Gegen were prepared by melting method. Using PEG 4000 and PEG 6000 as carrier. Serious of studies on the in yitro release kinetics were carried out.PEG4000 ; PEG6000 ratio had no effect on the release kinetics. PEG 4000: flavonoids ratio had an evident effect on the release properties of the pilulae, the higher the ratio,the faster the release rate. But when the PEG 4000, flavonoids ratio exceeded 10: 1, a reverse effect could be seen. Compared with 'Gegen flavonoids' tablets, 'Yufengingxin' tablets(release half time, T50= 94.79min), the pilulae gave a much fast release characteristic (T50 = 11. 56min).