尼维地平抗高血压治疗对大鼠局灶脑缺血的保护作用

Effects of antihypertensive therapy with nilvadipine

选用１２周的自发性高血压大鼠，皮下植入随渗透泵予尼维地平或其溶剂７ｄ（第１组）或１４ｄ（第２组）。用药后分别于第６、１３ｄ阻断左侧大脑中动脉。尼维地平治疗组血压降至正常。第１、２组应用尼维地平治疗后，梗塞灶体积较各自的对照组减少。冠状连续切片上梗塞灶面积在第１组仅有２张，而在第２组有５张缩小。第２组脑水肿体积亦减少。因此尼维地平对自发性高血压大鼠的局灶脑缺血具有疗程相关的保护作用，提示长期应用该药能减轻高血压患者脑卒中的病情。

The spontaneous hypertensive rat(SHR) 12 weeks old,received either nilvadipine (3mg/kg/day) or a vehiele subcutaneously. Group 1 was treated for 7 days, and Group 2 for 14 days. The left middle cerebral artery was occluded on the 6th (Group 1) or 13th(Group 2)day of the treatment,and neurological and neuropathological outcomes were quantified 24 hours later. The mean arterial blood pressures were reduced with nilvadipine to normal levels. The ncurological outcomes of groups 1 and 2 were better than those of the control group and the infarct volumes of groups 1 and 2 were less than those of their own controls. When infarct areas were compared in each of 8 coronal sections,the infarct size had decreased in the cach of 8 coronal sections, the infarct size had decreased in the 5 posterior sections in group 2 but only in 2 sections of Group 1.A significant decreasc in the edema volumes was observed in Group 2, but not in Group 1. Thus, nilvadipine provided protective effcts against cerebral ischemia in rats having chronic hypertension,and the effects were dependent on the duration of therapy. The results suggest that this antihypertensive drug may have the additional benefit of reducing the consequences of a possible later stroke in hypertensive patients under longterm care.