神经生长因子对急性缺血性脑水肿和内皮素变化的实验研究

The effect of nerve growth factor on brain edema and contents of endothelin- 1 in cerebral ischemic regions of Wistar rats

本实验应用放射免疫测定法和密度梯度法观察了神经生长因子对Ｗｉｓｔａｒ大鼠缺血皮层和血浆内皮素（ＥＴ－１）和脑皮层比重的影响。结果表明：脑缺血前后１０ｄ分别每天给予不同剂量的神经生长因子（２ｍｇ／ｋｇ、１ｍｇ／ｋｇ、２ｍｇ／ｋｇ、３ｍｇ／ｋｇ）能不同程度地影响脑缺血皮层中内皮素的变化，缺血性脑水肿也相应地得到改善，且呈量效依赖关系，为该药治疗脑血管病提供其理论依据。

The effect of nerve growth factor (NGF)on contents of endothelin- 1(ET-1) in cerebral ischemic regions of Wistar rats were observed with the radioimmunoassay and the specific gravity(Sp Gr) method in this study. The results showed that the contents of ET-1 were significantly decreased in ischemic brain cortex and specific gravity of brain edema were significantly increased with injection of NGF(2mg/kg、1mg/kg、2mg/kg、3mg/kg) into abdominal cavity of Wistar rats before and after cerebral ischemic in 10 days and showed dosedepandent