疟疾患者丙型肝炎病毒感染原因的血清学研究

Seroepidemiological Study on HCV Infection among Malaria Cases

本文报道了９７例疟疾患者丙型肝炎病毒（ＨＣＶ）感染的原因。发现疟疾患者抗－ＨＣＶ阳性率为７１．１３％，其中有单采血浆还输血细胞（下称单采浆）献血史者为８９．７１％，有受血史者为６４．２９％，既无单采浆史又无受血史者无一例抗－ＨＣＶ阳性。有单采浆史的疟疾患者与同村非疟疾的单采浆献血者相比，抗－ＨＣＶ阳性率无显著不同，且二者均显著高于同村既无单采浆史又无受血史的非疟疾人群。在无单采浆史和受血史人群中，疟疾病例和非病例抗－ＨＣＶ阳性率很低。说明有单采浆史的疟疾病例ＨＣＶ感染与单采浆有关，有受血史的疟疾病例ＨＣＶ感染与受血有关。对当地单采浆血站进行调查，发现在采血、分离血浆和血细胞还输过程中存在血液交叉污染，这是导致有单采浆史的疟疾病例ＨＣＶ感染的主要原因。

he causes of HCV infection among 97 malarla cases were studied in Hebei province.The results indicated that positive rates of anti-HCV were 71.13%for malaria cases.89.71%for those with history of plasmapheresis.64.29% for those with history of bloodtransfusion;no anti-HCV positlve was found for those with neither plasmapheresis nor bloodtransfusion. The rates were not significantly different betwecn malaria cases with history ofplasmapheresis and plasmapheresis donors at the same villages ,and it was very low amongthe malaria cases or non-malaria cases with neither plasmapheresis nor blood transfusion. Itwas showed that HCV infection of malaria cases was related to plasmaptiereses and bloodtrasfusion. By investigation the operatinq courses of taking blood,isolating plasma,and re-turn transfusion of blood cells at local plasmapheresis centers,Cross-contaimination of bloodwere found.and it was the main cause of HCV infection of malaria cases.