摘要
本实验采用ＦｅＳＯ＿４／抗坏血酸体系观察了氧自由基对大鼠心肌线粒体质子ＡＴＰ酶（Ｈ￣＋－ＡＴＰａｓｅ）水解与合成活性的损伤作用及丹参素（ＤＳ－１８２）的保护作用效应。结果表明：ＦｅＳＯ＿４／抗坏血酸体系产生的氧自由基可使线粒体Ｈ￣＋－ＡＴＰａｓｅ水解活性明显升高、合成活性明显下降，丹参素可以防止Ｈ￣＋－ＡＴＰａｓｅ水解活性升高，合成活性下降、显示出良好的保护作用。
An oxygen free radical generation system,FeSO_4/Ascorbic acid,was used to observe the effect of oxygen free radicals on the hydrolytic and synthetic acti-vities of H￣+-ATPase in rat myocardium mitochondria and the protective effect of DS-182.The results showed that FeSO_4/Ascorbic acid increased hydrolytic activity of H￣+-ATPase markedly, whereas the synthetic activity decreased tremendously. Salvianic acidDS-182)protected these activities(either hydrolytic or synthetic ) of H￣+-ATPase against oxygen free radicals injury.
出处
《中国病理生理杂志》
CSCD
北大核心
1995年第1期42-45,共4页
Chinese Journal of Pathophysiology
关键词
心肌
线粒体
丹参素
氧自由基
H^+-ATP酶
Free radicals
Myocardium
Salvianic acid
Mitochondria
H(+)-Transporting ATPase
