肽6A对球囊损伤后大鼠主动脉血管壁增殖的影响

Effect of peptide 6A on vascular cell proliferation induced by balloon angioplasty in rat aorta

本文在大鼠主动脉球囊内皮剥脱术后血管壁细胞过份增殖模型上，用合成的纤维蛋白（原）降解产物肽６Ａ（４０μｍｏｌ／ｋｇ／ｄ）治疗，可有效地抑制损伤血管壁的细胞计数增加和内膜增殖，显著降低其血管组织￣３Ｈ－ＴｄＲ和￣３Ｈ－Ｌｅｕ掺入增加程度，实验结果提示肽６Ａ作为血管成型术的辅佐剂，对于防治再狭窄可能具有潜在临床应用前景。

A vascular cell proliferation model was established by balloon angioplastyin rat aorta treated with synthetic peptide 6A(40 μmol/kg/day ),which is a degradationproduct of fibrinogen,the increase in cell count of injuried vascular wall, and incorpor-ation of￣3H-TdR and ￣3H-Leu of vascular tissues were inhibited effectively.These resultssuggest that peptide 6A as an adjuvant of balloon angioplasty might have clinically pros-pective significance in preyention and therapy of restenosis.