红丝线草醇提水转溶物对急性高血压猫心功能和血流动力学的影响

The effect of Hongsixian(HSX) on cardiac function and hemodynamics of acute hypertensive cats

本文报道红丝线草醇提水转溶物（ＯＬ－Ｗ）对急性高血压猫心功能和血流动力学的影响。实验结果表明：两种剂量（ＬＤ＿５０的１／５０、ＬＤ＿５０的１／３０）的ＯＬ－Ｗ静脉注射给药后：（１）可降低ＬＶＰ、ＭＢＰ、ＤＢＰ、ＳＢＰ、ＴＰＶＲ，均有非常显著性差异（Ｐ＜０．０１）。（２）降低ＬＶＷ，ＬＶＷＩ、ＬＶＳＷ、ＬＶＳＷＩ、ＴＴＩ、ＴＴｌ×ＨＲ，Ｐ值均＜０．０１。（３）改善心肌舒张性，包括缩短Ｔ，具有统计学意义（Ｐ＜０．０１）。综上所述，ＯＬ－Ｗ能显著降低高血压猫的血压，且能改善心室舒张功能。

This paper described the effect of alcohol extract of water soluble HSX(OL-W)on cardiac function and hemodynamics f acute hypertensive cats which wasopen-chest and anesthetized with urethane.Two doses(1/50 of LD_50 of OL-W,1/ 30 of LD_50of OL-W)was injected to femoral vein.The result showed that OL-W influenced var-ious cardiac indicated as follows:(1) Decreased contractility of cardiac muscle slightly(dp/dtmax、t-dp/dtmax,Vce-CPI;(2 ) Decreased cardiac output(CO、CI,SV、SI),butnot significantly(P>0.05 ) ;( 3)Decreased left ventricle work (LVW、 LVWI、LVSW、LVSMITTI、 TTI × HR)significantly(P<0.01).These results indicated that the consumption ofoxygen by cardiac muscle was decreased;(4)Decreased pre-load and after-load of hearttremendously(P<0.01)(LVP、 LVEDP、 SBP、 DBP、 MBP、 TPVR);(5)Decreased heartrate slightly;(6 ) Improved the diastolic function of heart(T)significantly(P<0.01).