摘要
本文报道红丝线草醇提水转溶物(OL-W)对急性高血压猫心功能和血流动力学的影响。实验结果表明:两种剂量(LD_50的1/50、LD_50的1/30)的OL-W静脉注射给药后:(1)可降低LVP、MBP、DBP、SBP、TPVR,均有非常显著性差异(P<0.01)。(2)降低LVW,LVWI、LVSW、LVSWI、TTI、TTl×HR,P值均<0.01。(3)改善心肌舒张性,包括缩短T,具有统计学意义(P<0.01)。综上所述,OL-W能显著降低高血压猫的血压,且能改善心室舒张功能。
This paper described the effect of alcohol extract of water soluble HSX(OL-W)on cardiac function and hemodynamics f acute hypertensive cats which wasopen-chest and anesthetized with urethane.Two doses(1/50 of LD_50 of OL-W,1/ 30 of LD_50of OL-W)was injected to femoral vein.The result showed that OL-W influenced var-ious cardiac indicated as follows:(1) Decreased contractility of cardiac muscle slightly(dp/dtmax、t-dp/dtmax,Vce-CPI;(2 ) Decreased cardiac output(CO、CI,SV、SI),butnot significantly(P>0.05 ) ;( 3)Decreased left ventricle work (LVW、 LVWI、LVSW、LVSMITTI、 TTI × HR)significantly(P<0.01).These results indicated that the consumption ofoxygen by cardiac muscle was decreased;(4)Decreased pre-load and after-load of hearttremendously(P<0.01)(LVP、 LVEDP、 SBP、 DBP、 MBP、 TPVR);(5)Decreased heartrate slightly;(6 ) Improved the diastolic function of heart(T)significantly(P<0.01).
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1995年第5期460-464,共5页
Chinese Journal of Pathophysiology
基金
广东省自然科学基金
广东省卫生厅和国务院侨办资助