慢性氟中毒大鼠肝细胞超微结构改变的体视学研究

A STEREOLOGIC STUDY OF HEPATOCYTIC ULTRASTRUCTURE ON RAT CHRONIC FLUOROSIS

用体视学方法计量两组大鼠肝细胞线粒体的体密度(Vvm)、面密度(Svm)、比表面(Qm)、面数密度(N_(Am)、规化形状因子(RFF)。结果表明染氟组大鼠肝细胞线粒体RFF显著减少(P<0.01);Vvm、Svm显著增高(P<0.005);Qm无显著差异。提示NaF能引起肝细胞线粒体的畸形和增生。

Using the stereologic method the following parameters of hepatocyte mitochondria were measured: volume density (Vvm) , surface density (Svm) , specific surface (Qm) , area number density (Nam) and regular form factor (RFF). The results showed : RFF in group F was very significantly decreased, Vvm, Svm in group F was very significantly increased and Qm in group F did not statistic difference. The results suggest that there may be compensatory proliferation and deformation of hepatocyte mitochondria in group F.