维生素E对大剂量维生素D_3所致心肌损伤的保护作用

Preventive effect of Vitamin E on myocardial damage induced by large dose Vitamin D_3

本实验以大剂量维生素Ｄ３作为条件因素建立动物心肌损伤模型，观察维生素Ｅ对心肌损伤的保护作用。结果，大剂量维生素Ｄ３能降低大鼠心肌呼吸酶（细胞色素氧化酶和琥珀酸脱氢酶）活性。明显降低血清维生素Ｅ含量，使大鼠血清、心肌、肝脏组织谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ）活性降低，脂质过氧化物（ＭＤＡ）含量升高。而预先给维生素Ｅ，能明显提高大鼠血清维生素Ｅ含量，提高呼吸酶活性．增强大鼠血清。心肌、肝脏组织ＧＳＨ—Ｐｘ活性，降低脂质过氧化物值。使大鼠心肌坏死面积明显减少。

The antagonistic effect of Vitamin E on large dose Vitamin D3 was studied. The results showed that overdose Vitamin D3 could decrease the activities of cytochrome oxidase and succinate dehydrogenase of myocardial mitochondria, and apparently reduce the content of Vitamin E in serum. Simutaneously,Vitamin D3 could in crease the level of MDA and lower the activities of GSH-Px in serum, myocardium and liver.However ,the inhibitory action of overdose Vitamin D3 on the enzymes could be markedly antagonized by the pretreatment with Vitamin E. The level of Vitamin E in serum was developed and MDA in serum, myocardium,liver was dropped in VE+VD group. It is suggested that Vitamin E can prevent the myocardial damage led by overdose Vitamin D3.