动脉粥样硬化高低发区冠状动脉壁胶原纤维的比较研究

Comparative Study of Collagens in Coronary Artery Walls between Atherosclerosis Higher and Lower Prevalence Location

为研究冠状动脉壁胶原纤维的年龄性变化及其与动脉粥样硬化的关系，木文收集动脉粥样硬化高发区（北京）和低发区（宁波）年轻人意外死亡者冠状动脉左前降支共２６支，用天狼星红染色、偏振光显微镜进行比较研究．结果是：随着动脉粥样硬化病变的发展，病变部位Ⅰ型和Ⅲ型胶原纤维逐渐增多；随着年龄增加，左前降支血管壁内膜Ⅰ型和Ⅲ型胶原纤维逐渐增多，Ⅰ型胶原纤维占优势．高发区胶原增多较低发区更明显。此可能为高发区动脉粥样硬化发生发展较快的局部因素之一．

In order to study collagens' change with aging and its relation to atherosclerosis,left anterior descending branches of 26 autopsies, aged 15 to 39 years,died by accidents, such as violence and traffic accidents were collected from Beijing (16), one of the atherosclerosis higher prevalence location. and Ningbo (10), one of the atherosclerosis lower prevalence location. They were stained picrosirius red and observed using polariscope. The results showed that collagens type Ⅰ and Ⅲ atherosclerotic had the trend of increasing with the development of atherosclerosis and also had the trend of increasing with aging in left anterior descending branches, type Ⅰwas in majority and it was more obvious in Beijing than in Ningbo,this may be susceptible to atherosclerosis.