L－精氨酸对高脂血症家兔血浆脂蛋白、一氧化氮和脂过氧化物的影响

Effect of L-arginine on Lipoprotein, Nitric Oxide and Lipid Peroxide in Hypercholesterolaemic Rabbits

用雄性新西兰白兔观察了Ｌ－精氨酸对高脂血症时血浆脂蛋白、血清一氧化氨、脂过氧化物和超氧化物歧化酶的影响。结果发现２％Ｌ－精氨酸与２％胆固醇同时喂养９０天，或喂养９０天以后４％Ｌ－精氨酸治疗９０天，均能有效地抑制高胆固醇所致的血清脂过氧化物的升高，提高高脂血症家兔血清超氧化物歧化酶活性，促进血管内皮细胞一氧化氮的释放。结果提示，Ｌ－精氨酸／一氧化氮可能有抗高脂血症家兔低密度脂蛋白氧化修饰的作用。

We reported the effect of L-arginine on lipoprotein, nitric oxide(NO), lipid peroxide (LPO) and superoxide dismutase (SOD) in hypercholesterolaemic rabbit. The results showed that 2% L-arginine fed in company with 2% cholesterol for 90 days and 4%L-argine orally administrated for 90 days after 2%L-arginine and 2% cholesterol could significantly protect the activity NO and SOD, decrease the LPO content. L-Arg/NO may reduce the oxidative modification of LDL of hypercholesterolaemic rabbit.