动脉粥样硬化高低发区人冠状动脉内膜平滑肌细胞结蛋白及胸腺素表达的比较

Expression of Desmin and Prothymosin in Coronary Arterial Smooth Muscle Cells of Subjects from Districts of High and Low Incidence of Atherosclerosis

用免疫组织化学方法研究北京、南宁和宁波青年人冠状动脉内膜平滑肌细胞中结蛋白和前胸腺素的表达情况。测得结蛋白阳性率的高低顺序为南宁、宁波、北京。南宁与北京的差别有显著性（Ｐ＝０．０００４），宁波与北京的差别有意义（Ｐ＝０．０１９），而南宁与宁波的差别无意义（Ｐ＝０．２１５６）。结蛋白可作为肌细胞分化的标志，提示南宁与宁波青年冠状动脉内膜平滑肌细胞向成熟分化，而北京人则缺乏这种倾向。前胸腺素阳性率顺序为北京、南宁、宁波。提示北京人冠状动脉内膜ＳＭＣ相对有较高的增长趋势。上述结果显示高低发区ＳＭＣ内部结构的差别。

Coronary arteries of youth from Beijing, Nanning and Ningbo were collected, taking ten cases from each district respectively. Desmin and prothymosin (PT) alpha in smooth muscle cells(SMC)of the intima of the coronary artery were detected using immunohistochemical method. Thedesmin positive rates in Nanning,Ningbo,and Beijing were in order of the frequency from high to low. By comparison the difference between Nanning and Beijing was dominant (P=0. 0004) and the difference between Ningbo and Beijing was significant (P=0. 019).While there was no statistical significance difference between Nanning and Ningbo (P=0.2156). It indicates that the SMC in the intima of the coronary artery are potentially differentiated into maturity in the youth of Nanning and Ningbo.However, in the youth of Beijing there is lack of thi potency. About the positive rates of PT,the order of frequency from high to lowwas Beijing,Nanning and Ningbo,though there was$中国人民解放军第113医院病理科