口服避孕药与动脉血压升高的关系及其机理探讨

Study on the relation between the oral contraceptive ane hypertension in women and its mechanism

观察25名长期口服避孕药妇女的血压和血浆心钠素(ANF)变化,血压增高者服药时间明显长于血压正常者(P<0.05),但血压与服药时间无直线相关关系(P>0.05)。血压增高者ANF明显增高(P<0.01),且服药者血压与血浆ANF呈高度正相关关系(P<0.01),提示口服避孕药引起血压升高与服药时间有一定关系,血压增高的程度不随服药时间的延长而增加。口服避孕药后的血压升高属高ANF型。

The blood pressure and the plasma level of atrial natriuretic factor(ANF)in 25 subjects using oral contraceptive were observed. The duration of administration in subjects with hypertension was longer than those with normal blood pressure ( P <0. 05). The pressure was not positively correlated with the duration ( P >0. 05). The ANF level in hypertension was higher than those normals( P <0. 01). A positive correlation exists between the ANF and the blood pressure( P <. 0. 01). The results indicated that the hypertension induced by oral contraception bore a relationship with the duration of administration but the blood pressure was not correlated with the duration and this hypertension is of 'the high ANF type'.