摘要
本文研究了氟对大鼠自然杀伤（ＮＫ）细胞和白细胞介素－２（ＩＬ－２）的影响以及硼对氟的拮抗作用。大鼠饮用含氟水（１１０ｍｇ￣（Ｆ－）／Ｌ）和氟硼混合水（１１０ｍｇ￣（Ｆ－）＋４４ｍｇ￣（Ｂ３＋）／Ｌ）４个月，以饮用自来水为对照。研究结果表明氟可抑制大鼠脾脏ＮＫ细胞和ＩＬ－２的活性；硼在体外与氟混合后饮用，可拮抗氟引起的ＮＫ细胞和ＩＬ－２活性的降低，并使尿氟排出增加，骨氟含量下降，提示硼可拮抗氟的毒性。
his paper explored the effect fluoride on the activity
of natural killer(NK )cells and interleukin-2(IL-2)in the rats′spleen ,as wellas the antagonistic
effect of boron to fluoride.Drinking water contained NaF(110mg F-/)and NaF+Borax(110mg￣
(F-)+44mB￣(3+)/L)wereadministered in two groups of rats,respecti-vely ,for 4 months ,the
control was given tap water.The results showed that fluoride could obviously reduce the
activity of Nk cells and IL-2,and that that boron ,mixed with fluoride,could antagonise the effect
of fluoride on the activity of NK cells and IL-2 ,and increase the excretion of fluoride in urine
,and reducethe content of fluoride in bone .The study suggests that boron may antagonise the
toxi-city of fluoride.
出处
《中国工业医学杂志》
CAS
1995年第1期7-8,共2页
Chinese Journal of Industrial Medicine
基金
中国有色金属总公司"八.五"项目
