二苯甲烷二异氰酸酯作业工人嗜碱粒细胞释放能力的研究

Study on the Basophil Releasablity inWorkers Exposed to Diphenylmethane Diisocyanate

３０例二苯甲烷二异氰酸酯（ＭＤＩ）作业工人和１２例哮喘患者的嗜碱粒细胞脱颗粒指数（ＤＩ）和嗜碱粒细胞脱颗粒试验（ＨＢＤＴ）阳性率均非常显著地高于３５例不接触ＭＤＩ的对照者；哮喘组ＤＩ与抗原特异性ＩｇＥＯＤ值高度相关（ｒ＝０．７７，Ｐ＜０．００１），与非特异性支气管激发试验的阳性符合率为７７．７８％；ＨＢＤＴ的诊断指效为１７２．１４％。结果表明，嗜碱粒细胞释放能力依赖于ＩｇＥ水平，在ＭＤＩ哮喘发病中起重要作用，可结合临床用于ＭＤＩ哮喘诊断。

he degrnulation index(DI)of the baso-phil releasability and the positive rates of the human basophil degranulation test(HBDT)in 30 workers exposed to MDI and 12patients with MDI-asthma were significa-ntly higher than those in 35 unexposedcontrols. There was higher correlationbetween Dl and Specific IgE OD valuesin 12 patients with MDI-asthma(r=0.77,P< 0.001).Agreement rate of HBDT waS 77.78%with non-specific bronchlal-provocation test.The diagnosis index of HBDT was 172.14%.The results showed that the basophil releasa-bility is dependent on IgG levels and plays animportant role in the mechanism of asthmadue to MDI. Clinical data should be cons-idered when HBDT is used in diagnosis of MDI-asthma.。