美托洛尔对高血压血液动力学的急性效应

The Acute Hemodynamic Effects after Metoprolol in Essential Hypertension Patients

用二维及多普勒超声心动图观察30例高血压病患者首次口服美托洛尔后其血液动力学的即刻效应。口服美托洛尔50mg后，血压、心率明显下降，血管顺应性、外周阻力增加；左心形态结构无明显改变；左室收缩功能指标FS、EF、CO、CI明显下降（P＜0．01），左室舒张功能参数E、EI增加，A、AI、A／E、AI／TI明显下降（P＜0．05），提示左室收缩功能减弱，舒张功能改善。

Using two-dimensional echocardiography and Doppler ultrasound techniques, the acute homodynamic effects after metoprolol were assessed in 30 patients with stage Ⅰ~ Ⅱ essential hypertbnsion. Metoprolol decreases heart rate,systolic and diastolic blood presure. IncreaseS in arterial compliance and decreases in cardiac output,indexes of cardiac output,ejection fraction, shortened fraction (P < 0. 01 ) were also shown. The peak velocity of early filling (E) and the time velocity intergrate of transmitral flow (EI) were increased. The peak velocity of late filling (A). the late time velocity intergrateof transmitral now(AI),and the ratio of A/E,AI/TI were decreased. Conclusion: after .administration of once oral dose of metoprolol,the left ventricular systolic function was attenuated,and diastolic function improved.